Now this is not quite the same a directly applying Obagi DuDerm Skin Care products including tretinoin to your hands but it is not as costly in my book either. In addition, the fragrance is pleasant as opposed to the hydroquinone products. Of course, you can still layer products on, the retinol contained in the hand creme is not as strong as prescription retinol but if you use it, as I do on my face at night. The retinol that remains on the back of my hand I just rub in and you can easily apply this hand creme on top of it. It feels wonderful!